Prof Jian Li
NHMRC PRF
Monash Institute of Pharmaceutical Sciences
Monash University
jian.li@monash.edu
Research Activities
Pharmacokinetics and pharmacodynamics of polymyxins against multidrug-resistant 'superbugs', in particular Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae (NHMRC and NIH funded projects)Mechanisms of activity and resistance of polymyxins (NIH and NHMRC funded projects)
Discovery of novel lipopeptides and natural products against Gram-negative polymyxin-resistant 'superbugs' (NIH and NHMRC funded projects)
Combination of antimicrobial agents (NHMRC and NIH funded projects)
Chemotherapy for infections in patients with cystic fibrosis
Novel anti-pathogenic agents
Integration of pharmacokinetic and pharmacodynamic principles to assist in antimicrobial development, to reduce resistance development and to optimize efficacy in the clinical use of antimicrobial agents
Lead optimisation of new antimicrobial entitiesPhage pharmacology and therapy
Techniques/Expertise
Susceptibility testing including: minimum inhibitory and bactericidal concentrations; fractional inhibition concentrations (for combinations); population analysis profilesTime-kill experiments and post-antibiotic effect experiments (in vitro and in vivo)
In vitro Pharmacokinetic/Pharmacodynamic (PK/PD) infection model
In vitro biofilm model
Animal infection models (mouse thigh and mouse lung)
Quantitative analysis of drugs in biological fluids (using HPLC, LC/MS and bioassays) Pharmacokinetics of antimicrobials in small animals, including hepatic and renal handling of drugs and metabolites
Structure-activity relationships of polymyxin peptides against Gram-negative pathogens
Discovery and purification of novel antimicrobial agents from natural products
Collaborations
Professor John Turnidge (Women's and Children's Hospital)Professor David Paterson (Royal Brisbane and Women's Hospital)
Associate Professor Denis Spelman (Alfred Hospital)
Professor Jeff Lipman (University of Queensland)
Drs Ian Larson, Tony Velkov, Phil Thompson, Jamie Simpson, Ben Boyd, David Morton, Richard Prankerd, Michelle McIntosh and Prof Chris Porter (Monash Institute of Pharmaceutical Sciences, Monash University)
Dr Alexandre Prehn Zavascki (Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul, Brazil)
Professor Yue-zhong Li (Shandong University, China)
Prof Roger Nation
Dr Marina Harper
Prof Brian Tsuji (USA)
Prof John Boyce
Prof Ben Howden
Disease Models
Mouse thigh infection modelMouse lung infection modelMouse bloodstream infection modelMouse UTI infection modelMouse wound infection modelMouse and rat pharmacokinetics models
