A/Prof Aaron Irving
Group Leader
ZJU-UoE Institute,
Zhejiang University School of Medicine
aaronirving@intl.zju.edu.cn
Research Activities
Pattern recognition receptors and activation of innate immunity and the inflammasome.Viral infection and innate immunity, Host-pathogen interactions.
Differences in innate immune activation and inflammasome sensing between bats and humans and applications to human health - comparative immunology.
Techniques/Expertise
Mammalian cell culture (epithelial cells, bone marrow derived macrophages/dcs, macrophage lines, T cell lines, PBMCs, lung, liver, kidney, whole splenocytes)Immuno-detection techniques (eg. ELISA, Western blotting, flow cytometry)
inflammasome activation
NGS and proteomics
TLR ligand screening
Gene knockdown (RNAi)
Confocal and live-cell microscopy
Molecular Biology (cloning, mutagenesis, library screening)
Viral infection assays (NBV, HeV, SeV, MuV, Zika, DV, SFV, Adv5, HSV1, EMCV, RSV, VZV)
Cellular movement (cellular migration, phagocytic uptake)
Disease Models
inflammasomevirus infections
primary cells
primary bat cells
in vivo bat infections
MERS-CoV, SARS-CoV-2, PRV, IAV, HSV, DENV, ZIKV, bat IAVs
Genetically Modified Organisms
micebat (KO cells)
